This paper also presents data on biofilm formation and lethal dose in Galleria mellonella there is little published information describing these aspects of virulence. The other assemblies available consist of 37, 38, 111 and 227 contigs. This paper presents the first ONT/Illu- mina hybrid assembly, with five contigs. pauculus two of these are PacBio/Illumina hybrids.
There are only six genome assemblies available on NCBI for C. pauculus strain isolated from a hospital sink trap. Hospital sink traps can serve as a niche for bacterial persistence and a platform for horizontal gene trans- fer, with evidence of dissemination of pathogens in hospital plumbing systems driving nosocomial infection. This pathogen should be considered responsible for infections that usually develop in immunocompromised patients.Ĭupriavidus pauculus is historically found in soil and water but has more recently been reported to cause human infection and death. : Clinical improvement cannot always be expected in spite of targeted antibiotic therapy. The patient died eleven days after admission. The diagnosis of multiple organ dysfunction syndrome (MODS) caused by C.
There was a poor clinical response despite repeated blood culture showing negative results. Tracheal aspirate culture and blood culture showed bacterial growth of Cupriavidus pauculus. Parenteral ciprofloxacin and ceftriaxone were administered.
A chest X-ray showed bilateral infiltration. Investigations revealed elevated lactate and C-reactive protein levels. Examination revealed diminished bilateral vesicular breath sounds, fever, intense yellow tracheal secretions, a respiratory rate of 24/minute, a heart rate of 123/minute, and blood pressure of 75/55 mmHg. The patient was diagnosed with bilateral pneumonia, pulmonary sepsis and underwent invasive mechanical ventilation. : A 67-year-old man was admitted to the Intensive Care Unit with acute respiratory failure.
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